| 2021-01-17 11:00:00Sun 17-Jan-2021 | St. George’s FC vs Swieqi United FC | 11:00:00Postponed | Centenary Stadium |
| 2021-01-17 14:00:00Sun 17-Jan-2021 | Pieta’ Hotspurs FC vs Pembroke Athleta FC | 14:00:0014:00 | Victor Tedesco Stadium |
| 2021-01-17 15:00:00Sun 17-Jan-2021 | Mqabba FC vs Zebbug Rangers FC | 15:00:0015:00 | Centenary Stadium |
| 2021-01-17 18:00:00Sun 17-Jan-2021 | Naxxar Lions FC vs Qormi FC | 18:00:0018:00 | Victor Tedesco Stadium |
| 2021-01-17 19:00:00Sun 17-Jan-2021 | Vittoriosa Stars FC vs Marsa FC | 19:00:0019:00 | Centenary Stadium |
| 2021-01-20 20:30:00Wed 20-Jan-2021 | Naxxar Lions FC vs Pembroke Athleta FC | 20:30:0020:30 | Victor Tedesco Stadium |
| 2021-01-23 14:00:00Sat 23-Jan-2021 | Swieqi United FC vs Naxxar Lions FC | 14:00:0014:00 | Centenary Stadium |
| 2021-01-23 18:00:00Sat 23-Jan-2021 | Marsa FC vs St. George's FC | 18:00:0018:00 | Centenary Stadium |
| 2021-01-24 11:00:00Sun 24-Jan-2021 | Pembroke Athleta FC vs Marsaxlokk FC | 11:00:0011:00 | Centenary Stadium |
| 2021-01-24 14:00:00Sun 24-Jan-2021 | St. Andrews FC vs Qrendi FC | 14:00:0014:00 | Victor Tedesco Stadium |
| 2021-01-24 15:00:00Sun 24-Jan-2021 | Zebbug Rangers FC vs Fgura United FC | 15:00:0015:00 | Centenary Stadium |
| 2021-01-24 18:00:00Sun 24-Jan-2021 | San Gwann FC vs Vittoriosa Stars FC | 18:00:0018:00 | Victor Tedesco Stadium |
| 2021-01-24 19:00:00Sun 24-Jan-2021 | Qormi FC vs Pieta' Hotspurs FC | 19:00:0019:00 | Centenary Stadium |
| 2021-01-30 14:00:00Sat 30-Jan-2021 | Qrendi FC vs Zebbug Rangers FC | 14:00:0014:00 | Centenary Stadium |
| 2021-01-30 18:00:00Sat 30-Jan-2021 | Pieta’ Hotspurs FC vs Swieqi United FC | 18:00:0018:00 | Centenary Stadium |
| 2021-01-31 11:00:00Sun 31-Jan-2021 | Vittoriosa Stars FC vs St. Andrews FC | 11:00:0011:00 | Centenary Stadium |
| 2021-01-31 14:00:00Sun 31-Jan-2021 | St. George’s FC vs San Gwann FC | 14:00:0014:00 | Victor Tedesco Stadium |
| 2021-01-31 15:00:00Sun 31-Jan-2021 | Qormi FC vs Pembroke Athleta FC | 15:00:0015:00 | Centenary Stadium |
| 2021-01-31 18:00:00Sun 31-Jan-2021 | Marsaxlokk FC vs Mqabba FC | 18:00:0018:00 | Victor Tedesco Stadium |
| 2021-01-31 19:00:00Sun 31-Jan-2021 | Naxxar Lions FC vs Marsa FC | 19:00:0019:00 | Centenary Stadium |
| 2021-02-06 14:00:00Sat 6-Feb-2021 | San Gwann FC vs Naxxar Lions FC | 14:00:0014:00 | Centenary Stadium |
| 2021-02-06 18:00:00Sat 6-Feb-2021 | Pembroke Athleta FC vs Mqabba FC | 18:00:0018:00 | Centenary Stadium |
| 2021-02-07 11:00:00Sun 7-Feb-2021 | Zebbug Rangers FC vs Vittoriosa Stars FC | 11:00:0011:00 | Centenary Stadium |
| 2021-02-07 14:00:00Sun 7-Feb-2021 | St. George’s FC vs St. Andrews FC | 14:00:0014:00 | Victor Tedesco Stadium |
| 2021-02-07 15:00:00Sun 7-Feb-2021 | Fgura United FC vs Marsaxlokk FC | 15:00:0015:00 | Centenary Stadium |
| 2021-02-07 18:00:00Sun 7-Feb-2021 | Swieqi United FC vs Qormi FC | 18:00:0018:00 | Victor Tedesco Stadium |
| 2021-02-07 19:00:00Sun 7-Feb-2021 | Marsa FC vs Pieta' Hotspurs FC | 19:00:0019:00 | Centenary Stadium |
| 2021-02-13 14:00:00Sat 13-Feb-2021 | Naxxar Lions FC vs St. Andrews FC | 14:00:0014:00 | Centenary Stadium |
| 2021-02-13 18:00:00Sat 13-Feb-2021 | Marsaxlokk FC vs Qrendi FC | 18:00:0018:00 | Centenary Stadium |
| 2021-02-14 11:00:00Sun 14-Feb-2021 | St. George’s FC vs Zebbug Rangers FC | 11:00:0011:00 | Centenary Stadium |
| 2021-02-14 14:00:00Sun 14-Feb-2021 | Mqabba FC vs Fgura United FC | 14:00:0014:00 | Victor Tedesco Stadium |
| 2021-02-14 15:00:00Sun 14-Feb-2021 | Qormi FC vs Marsa FC | 15:00:0015:00 | Centenary Stadium |
| 2021-02-14 18:00:00Sun 14-Feb-2021 | Pieta’ Hotspurs FC vs San Gwann FC | 18:00:0018:00 | Victor Tedesco Stadium |
| 2021-02-14 19:00:00Sun 14-Feb-2021 | Swieqi United FC vs Pembroke Athleta FC | 19:00:0019:00 | Centenary Stadium |
