| 2021-01-21 20:15:00Thu 21-Jan-2021 | Zurrieq FC Youths vs Kalkara United FC Youths | 20:15:0020:15 | Zurrieq Ground |
| 2021-01-21 20:15:00Thu 21-Jan-2021 | Gharghur FC Youths vs Marsaskala FC Youths | 20:15:0020:15 | St. Patrick Ground |
| 2021-01-21 20:15:00Thu 21-Jan-2021 | Senglea Athletic FC Youths vs Siggiewi FC Youths | 20:15:0020:15 | Marsaskala Ground |
| 2021-01-21 20:15:00Thu 21-Jan-2021 | Sta. Venera Lightnings FC Youths vs Gzira United FC Youths | 20:15:0020:15 | Marsaxlokk Ground |
| 2021-01-21 20:15:00Thu 21-Jan-2021 | Ta’ Xbiex SC Youths vs Dingli Swallows FC Youths | 20:15:0020:15 | Mgarr Ground |
| 2021-01-21 20:30:00Thu 21-Jan-2021 | Mtarfa FC Youths vs Xghajra Tornados FC Youths | 20:30:0020:30 | Rabat Ajax Ground |
| 2021-01-28 20:15:00Thu 28-Jan-2021 | Kalkara United FC Youths vs Xghajra Tornados FC Youths | 20:15:0020:15 | Ghaxaq Ground |
| 2021-01-28 20:15:00Thu 28-Jan-2021 | Zurrieq FC Youths vs Gharghur FC Youths | 20:15:0020:15 | Zurrieq Ground |
| 2021-01-28 20:15:00Thu 28-Jan-2021 | Siggiewi FC Youths vs Mtarfa FC Youths | 20:15:0020:15 | Siggiewi Ground |
| 2021-01-28 20:15:00Thu 28-Jan-2021 | Marsaskala FC Youths vs Sta. Venera Lightnings FC Youths | 20:15:0020:15 | Marsaskala Ground |
| 2021-01-28 20:15:00Thu 28-Jan-2021 | Gzira United FC Youths vs Ta' Xbiex SC Youths | 20:15:0020:15 | St. Patrick Ground |
| 2021-01-28 20:45:00Thu 28-Jan-2021 | Dingli Swallows FC Youths vs Senglea Athletic FC Youths | 20:45:0020:45 | Dingli Ground |
| 2021-02-04 20:15:00Thu 4-Feb-2021 | Xghajra Tornados FC Youths vs Siggiewi FC Youths | 20:15:0020:15 | Ghaxaq Ground |
| 2021-02-04 20:15:00Thu 4-Feb-2021 | Gharghur FC Youths vs Kalkara United FC Youths | 20:15:0020:15 | Zurrieq Ground |
| 2021-02-04 20:15:00Thu 4-Feb-2021 | Sta. Venera Lightnings FC Youths vs Zurrieq FC Youths | 20:15:0020:15 | Siggiewi Ground |
| 2021-02-04 20:15:00Thu 4-Feb-2021 | Ta’ Xbiex SC Youths vs Marsaskala FC Youths | 20:15:0020:15 | Marsaxlokk Ground |
| 2021-02-04 20:15:00Thu 4-Feb-2021 | Senglea Athletic FC Youths vs Gzira United FC Youths | 20:15:0020:15 | Marsaskala Ground |
| 2021-02-04 20:30:00Thu 4-Feb-2021 | Mtarfa FC Youths vs Dingli Swallows FC Youths | 20:30:0020:30 | Rabat Ajax Ground |
| 2021-02-11 20:15:00Thu 11-Feb-2021 | Kalkara United FC Youths vs Siggiewi FC Youths | 20:15:0020:15 | Marsaxlokk Ground |
| 2021-02-11 20:15:00Thu 11-Feb-2021 | Gharghur FC Youths vs Sta. Venera Lightnings FC Youths | 20:15:0020:15 | Ghaxaq Ground |
| 2021-02-11 20:15:00Thu 11-Feb-2021 | Zurrieq FC Youths vs Ta' Xbiex SC Youths | 20:15:0020:15 | Zurrieq Ground |
| 2021-02-11 20:15:00Thu 11-Feb-2021 | Gzira United FC Youths vs Mtarfa FC Youths | 20:15:0020:15 | Pembroke Ground |
| 2021-02-11 20:15:00Thu 11-Feb-2021 | Marsaskala FC Youths vs Senglea Athletic FC Youths | 20:15:0020:15 | Marsaskala Ground |
| 2021-02-11 20:45:00Thu 11-Feb-2021 | Dingli Swallows FC Youths vs Xghajra Tornados FC Youths | 20:45:0020:45 | Dingli Ground |
