Siggiewi FC withdrew from the competition.
National Youth League Section D 2021/22
| Pos | Club | P | W | D | L | F | A | +/- | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 |  Gzira U. Youths | 8 | 5 | 2 | 1 | 13 | 8 | 5 | 17 |
| 2 |  Ta' Xbiex Youths | 7 | 4 | 1 | 2 | 14 | 10 | 4 | 13 |
| 3 |  Dingli S. Youths | 7 | 4 | 0 | 3 | 12 | 7 | 5 | 12 |
| 4 |  Gharghur Youths | 7 | 3 | 3 | 1 | 14 | 12 | 2 | 12 |
| 5 |  Kalkara U. Youths | 7 | 3 | 2 | 2 | 7 | 8 | -1 | 11 |
| 6 |  Zurrieq Youths | 9 | 3 | 1 | 5 | 13 | 14 | -1 | 10 |
| 7 |  Sta. Venera L. Youths | 8 | 2 | 4 | 2 | 10 | 11 | -1 | 10 |
| 8 |  Marsaskala Youths | 7 | 2 | 2 | 3 | 6 | 6 | 0 | 8 |
| 9 |  Senglea A. Youths | 7 | 2 | 2 | 3 | 7 | 9 | -2 | 8 |
| 10 |  Xghajra T. Youths | 7 | 0 | 1 | 6 | 6 | 17 | -11 | 1 |
