Siggiewi FC withdrew from the competition.
National Youth League Section D 2021/22
| Pos | Club | P | W | D | L | F | A | +/- | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 |  Gzira U. Youths | 2 | 2 | 0 | 0 | 5 | 2 | 3 | 6 |
| 2 |  Ta' Xbiex Youths | 2 | 2 | 0 | 0 | 5 | 3 | 2 | 6 |
| 3 |  Marsaskala Youths | 1 | 1 | 0 | 0 | 2 | 0 | 2 | 3 |
| 4 |  Sta. Venera L. Youths | 2 | 0 | 2 | 0 | 2 | 2 | 0 | 2 |
| 5 |  Gharghur Youths | 1 | 0 | 1 | 0 | 2 | 2 | 0 | 1 |
| 6 |  Xghajra T. Youths | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 |
| 7 |  Zurrieq Youths | 2 | 0 | 1 | 1 | 4 | 5 | -1 | 1 |
| 8 |  Senglea A. Youths | 2 | 0 | 1 | 1 | 2 | 3 | -1 | 1 |
| 9 |  Kalkara U. Youths | 1 | 0 | 0 | 1 | 0 | 2 | -2 | 0 |
| 10 |  Dingli S. Youths | 2 | 0 | 0 | 2 | 2 | 5 | -3 | 0 |
