Pembroke Athleta and Marsaxlokk promoted to the Premier League.
Vittoriosa Stars, Rabat Ajax and St. George’s relegated to the National Amateur League.
BOV Challenge League Group A 2021/22
| Pos | Club | P | W | D | L | F | A | +/- | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 |  Pembroke A. | 20 | 14 | 6 | 0 | 49 | 16 | 33 | 48 |
| 2 |  Marsaxlokk | 20 | 13 | 2 | 5 | 40 | 22 | 18 | 41 |
| 3 |  Zejtun C. | 20 | 12 | 4 | 4 | 44 | 24 | 20 | 40 |
| 4 |  Naxxar L. | 20 | 12 | 1 | 7 | 37 | 22 | 15 | 37 |
| 5 |  Melita | 20 | 10 | 3 | 7 | 28 | 22 | 6 | 33 |
| 6 |  San Gwann | 20 | 8 | 6 | 6 | 38 | 22 | 16 | 30 |
| 7 |  Lija A. | 20 | 8 | 4 | 8 | 39 | 37 | 2 | 28 |
| 8 |  Mqabba | 20 | 5 | 5 | 10 | 29 | 41 | -12 | 20 |
| 9 |  Vittoriosa S. | 20 | 5 | 1 | 14 | 23 | 61 | -38 | 16 |
| 10 |  Rabat A. | 20 | 3 | 4 | 13 | 20 | 42 | -22 | 13 |
| 11 |  St. George's | 20 | 1 | 2 | 17 | 13 | 51 | -38 | 5 |
