Zebbug Rangers and Pieta’ Hotspurs promoted to the Premier League
Senglea Athletic, Mgarr United and Luqa St. Andrew’s relegated to the National Amateur League.
Marsa had two points deducted by the Malta FA Control, Disciplinary and Ethics Committee
BOV Challenge League Group B 2021/22
| Pos | Club | P | W | D | L | F | A | +/- | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 |  Zebbug R. | 20 | 14 | 3 | 3 | 46 | 15 | 31 | 45 |
| 2 |  Pietà H. | 20 | 12 | 4 | 4 | 39 | 19 | 20 | 40 |
| 3 |  Tarxien R. | 20 | 10 | 8 | 2 | 45 | 24 | 21 | 38 |
| 4 |  Marsa | 20 | 10 | 5 | 5 | 35 | 22 | 13 | 33 |
| 5 |  Fgura U. | 20 | 9 | 4 | 7 | 35 | 27 | 8 | 31 |
| 6 |  St. Andrews | 20 | 8 | 4 | 8 | 36 | 30 | 6 | 28 |
| 7 |  Qrendi | 20 | 7 | 3 | 10 | 30 | 37 | -7 | 24 |
| 8 |  Swieqi U. | 20 | 5 | 9 | 6 | 21 | 29 | -8 | 24 |
| 9 |  Senglea A. | 20 | 4 | 3 | 13 | 24 | 50 | -26 | 15 |
| 10 |  Mgarr U. | 20 | 3 | 5 | 12 | 11 | 36 | -25 | 14 |
| 11 |  Luqa SA | 20 | 2 | 4 | 14 | 9 | 42 | -33 | 10 |
